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The NYPD began using the ForTwo in 2016 as a replacement for its three-wheel motorbikes. The department reportedly worked out a deal with Smart USA for no fewer than 250 units. What made the city car appealing to law enforcers? Well, believe it or not, it was space. Because while the Fortwo has a cramped interior compared to other vehicles, it offers way more room than the three-wheel motorbikes the NYPD had used for over a decade.
Most departments use third- and fourth-generation cars. Both pair 1.8-liter Atkinson-cycle gasoline engines to electric motors. The fourth-gen car is obviously the more advanced one, featuring a dual motor-generator setup and a total output of 120 horsepower.

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Chimeric antigen receptors (CAR)-T cells are genetically engineered T-lymphocytes redirected with a predefined specificity to any target antigen, in a non-HLA restricted manner, therefore combining antibody-type specificity with effector T-cell function. This strategy was developed some thirty years ago, after extensive work established the key role of the immune system against cancer. The first-engineered T-cell with chimeric molecule was designed in 1993 by Israeli immunologist Zelig Eshhar. Since then, several modifications took place, including the addition of co-stimulatory domain, to further improve CAR-T cell anti-tumor potency. The first clinical application of CAR-T cell was done in Rotterdam in 2005 for metastatic renal cell carcinoma and simultaneously at the National Cancer Institute (NCI) for metastatic ovarian cancer. These pioneered studies failed to demonstrate a therapeutic benefit, but warning emerged concerning their safety of use. The real clinical success came with anti-CD19 CAR-T cells, used since 2009 by Steven Rosenberg at the NCI in a patient with refractory follicular lymphoma and in 2011 by Carl June and David Porter from the University of Pennsylvania in patients with chronic lymphocytic leukemia and B-cell acute lymphoblastic leukemia. From that time, large centers in North America have embarked in several early phase and pivotal trials that have demonstrated unprecedent response rate in heavily pretreated chemo refractory patient with B-cell malignancies. Theses clinical success have led to the approval of three anti-CD19 CAR-T cells products for the management of B-cell malignancies in the United States and in Europe as of December 2020.
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To avoid errors caused by variations in the car's supply voltage due to electrical load and generator speed, a voltage stabilizer is included in the instrument circuit . The voltage stabilizer also works on the bi-metallic strip principle and keeps the instruments supplied at a steady 8 or 10 volts .
The output motor torque is determined by:

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